LDL

Can be produced directly ¹

Small VLDL₂ / large IDL₁ lead to mid sized LDL₂, while small IDL₂which is similar in size and density to large LDL¹, is the metabolic precursor to these particles. IDL₁ is part of a delipidation cascade, thus we go VLDL->IDL -> LDL, but IDL₂ is directly secreted (possibly in the liver), and thus the arising LDL remains in the same size and density region.

References

¹Gaw, A., C. J. Packard, G. M. Lindsay, B. A. Griffin, M. J. Caslake, A. R. Lorimer, and J. Shepherd. 1995. Overproduction of small very low density lipoproteins (Sf 20–60) in moderate hypercholesterolemia: relationships between apolipoprotein B kinetics and plasma lipoproteins. J. Lipid Res. 36: 158–171.

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