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ApoB

by on February 28, 2011

Secreted throughout the VLDL-LDL-IDL spectrum 1,2,3. Inversely related to TGs4, such that at low TG ApoB is released as IDL / LDL but at high TG 90% of ApoB is secreted in VLDL

References

1Fisher, W. R., L. A. Zech, L. L. Kilgore, and P. W. Stacpoole. 1991.Metabolic pathways of apolipoprotein B in heterozygous familial hypercholesterolemia: studies with a [3H]leucine tracer. J. Lipid Res. 32: 1823–1836.

2Soutar, A. K., N. B. Myant, and G. R. Thompson. 1977. Simultaneous measurement of apolipoprotein B turnover in very-lowand low-density lipoproteins in familial hypercholesterolaemia. Atherosclerosis. 28: 247–256.

3Nakaya, N., B. H. Chung, J. R. Patsch, and O. D. Taunton. 1977. Synthesis and release of low density lipoproteins by the isolated perfused pig liver. J. Biol. Chem. 252: 7530–7533.

4Packard, C. J., T. Demant, J. P. Stewart, D. Bedford, M. J. Caslake, G. Schwertfeger, A. Bedynek, J. Shepherd, and D. Seidel. 2000. Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions. J. Lipid Res. 41: 305–318.

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