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VLDL

by on February 24, 2011

Large VLDL (VLDL1) have less cholesterol ester and more triglyceride.

VLDL2 largely arises from VLDL1 as indicated by by a 90% reduction is rate of this conversion in lipoprotein lipase deficiency1,2 although some also arises from the liver.

Uptake of VLDL, that has not been degraded into VLDL remnants, may occur through the VLDL receptor3, dependent on ApoE. LRP receptor may uptake VLDL remnants4. An inverse relationship between VLDL size and LDL size has been suggested 5, although this has not been substantiated by my own, more recent research 6

References
1Packard, C. J., A. Gaw, T. Demant, and J. Shepherd. 1995. Development and application of a multicompartmental model to study very low density lipoprotein subfraction metabolism.J. Lipid Res.36:172–187.

2Stalenhoef, A. F., M. J. Malloy, J. P. Kane, and R. J. Havel. 1984. Metabolism of apolipoproteins B-48 and B-100 of triglyceriderich
lipoproteins in normal and lipoprotein lipase-deficient humans. Proc. Natl. Acad. Sci. USA. 81: 1839–1843.

3Tacken, P. J., B. Teusink, M. C. Jong, D. Harats, L. M. Havekes, K. W. van Dijk, and M. H. Hofker. 2000. LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice. J. Lipid Res. 41: 2055–2062.

4Hussain, M. M., F. R. Maxfield, J. Mas-Oliva, I. Tabas, Z. S. Ji, T. L. Innerarity, and R. W. Mahley. 1991. Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/ alpha 2-macroglobulin receptor. J. Biol. Chem. 266: 13936–13940.

5 Ref missing

6Wood, A.C., Glasser, S., Garvey, W.T., Kabagambe, E.K., Borecki, I.E., Tiwari, H.K., Tsai, M., Hopkins, P., Ordovas, J., & Arnett, D. K., How do VLDL, LDL and HDL lipoprotein diameters cluster across the components of the metabolic syndrome? submitted

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